The 1990s and 2000s were also marked by important epidemiological and intervention studies that focused on the translational impact of recent vitamin K discoveries, notably with respect to bone and cardiovascular health.
The decades that followed saw the discovery of additional VKDPs showing wide tissue distribution and functional scope, the latest members having been identified in 2008. Important studies relating to the role of vitamin K in sphingolipid synthesis were also underway at that time and would pave the way to further work 15 years later. The 1970s also saw an important breakthrough with respect to our understanding of the vitamin K cycle and marked the discovery of the first bone VKDP, osteocalcin. This discovery not only provided the basis to understanding earlier findings about prothrombin but later led to the discovery of vitamin K-dependent proteins (VKDPs) not involved in hemostasis. However, major progress in our understanding of the mechanisms of action of vitamin K came in the 1970s with the discovery of γ-carboxyglutamic acid (Gla), a new amino acid common to all vitamin K proteins. Introduction to the exciting history of discovery of Papua, with Jan Carstensz, Heinrich Harrer, and Michael Rockefeller. The work of Discovery Institute is disseminated through. The Discovery Center is a hometown, non-profit preschool and childcare center established in 1976 that has been dedicated to providing a quality program to children ages 6 weeks to 6 years. The Institute was founded by Bruce Chapman and George Gilder in 1991.
#The discovery free#
In the early 1940s, the first vitamin K antagonists were discovered and crystallized with one of its derivatives, warfarin, still being widely used in today's clinical setting. Discovery Institute has a special concern for the role that science and technology play in our culture and how they can advance free markets, illuminate public policy and support the theistic foundations of the West. In the decade that followed, the principal K vitamers, phylloquinone and the menaquinones, were isolated and fully characterized. Vitamin K was discovered fortuitously in 1929 as part of experiments on sterol metabolism and was immediately associated with blood coagulation.